PGD (Pre-Implantation-Genetic Diagnosis) + FISH

The chromosome set of a person determines his life from the moment of conception. Physical appearance, mental abilities, functioning of internal organs and systems depend on genetics. In case of failure in the genetic program, the embryo may stop developing before implantation or at any stage of pregnancy. In addition, a child may be born with a severe genetic disorder.

Up to 50-60% of early miscarriages are caused by the presence of chromosomal abnormalities in the embryo. Spontaneous abortions before 12 weeks of gestation are mainly due to genetic abnormalities in the fetus. The frequency of occurrence of chromosomal and gene abnormalities depends on the parents’ age. The age of a woman is particularly important, since the number and quality of eggs decreases after the age of 35.

There are about 800 variants of chromosomal abnormalities associated with a change in the number and structure of chromosomes. A unique method of Preimplantation Genetic Diagnosis or PGD allows identifying the abnormalities before pregnancy, thereby preventing genetic pathologies in the fetus. This method is used only in IVF / ICSI programs. It is noteworthy that more and more couples resort to PGD without hereditary diseases - they just want to be calm about the health of their unborn baby.

Fluorescence in situ hybridization (FISH) is one of the methods of PGD, which is carried out as part of IVF. FISH involves the selection of healthy embryos without chromosomal abnormalities and their transfer to the uterus. FISH allows parents-to-be to examine five chromosomes, such Down syndrome, Trisomy 13, Trisomy 18, as well as XX (female) and XY (male) chromosomes (Gender (Sex) Selection) of the embryo.

PGD by the FISH method is performed on the 3d or 5th day of the embryo's development, which allows obtaining more accurate and detailed information about its chromosome set.

Benefits of FISH diagnostics on the 5th day of embryo development:

  • all embryos that have reached the blastocyst stage are examined (a high potential for further successful development);
  • it is possible to collect more cells for research (than on the 3rd day of development) without harm to the embryo;
  • a high rate of embryo implantation
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